MolNFT v1 · #103720 · protein

Fab fragment of der P 1 specific antibody 10B9

4POZ · Light chain of Fab fragment of 10B9 antibody: “Fab fragment of der P 1 specific antibody 10B9”. X-ray diffraction, 5 pockets (best druggability 0.52). MolNFT v1 #103720 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4POZ
Type: protein
Length: 426 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Light chain of Fab fragment of 10B9 antibody; Heavy chain of Fab fragment of 10B9 antibody
Pockets: 5 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Light chain of Fab fragment of 10B9 antibody	protein	211	6% helix, 51% strand	—
D	Heavy chain of Fab fragment of 10B9 antibody	protein	215	9% helix, 53% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	319	0.52	0.74	40	empty
2	66	0.45	0.83	24	empty
3	100	0.36	0.74	18	empty
4	66	0.32	0.75	18	empty
5	55	0.28	0.74	17	empty

Interfaces

1 interface between chains.

C–D · 1928 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4POZ · Fab fragment of Der p 1 specific antibody 10B9 · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4POZ · PDBe 4POZ

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