MolNFT v1 · #103651 · protein
Structure of S. pombe PCT1 RNA triphosphatase
4PN0 · MRNA-capping enzyme subunit beta: “Structure of S. pombe PCT1 RNA triphosphatase”. X-ray diffraction, 7 pockets (best druggability 0.68). MolNFT v1 #103651 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4PN0
- Type
- protein
- Length
- 1,034 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MRNA-capping enzyme subunit beta
- EC
- 3.1.3.33
- UniProt
- Q9P6Q6
- Pockets
- 7 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 25% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MRNA-capping enzyme subunit beta (EC 3.1.3.33) | protein | 261 | 26% helix, 38% strand | Q9P6Q6 |
| B | MRNA-capping enzyme subunit beta (EC 3.1.3.33) | protein | 260 | 26% helix, 38% strand | Q9P6Q6 |
| C | MRNA-capping enzyme subunit beta (EC 3.1.3.33) | protein | 256 | 25% helix, 38% strand | Q9P6Q6 |
| D | MRNA-capping enzyme subunit beta (EC 3.1.3.33) | protein | 257 | 23% helix, 38% strand | Q9P6Q6 |
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 492 | 0.68 | 0.79 | 54 | empty |
| 2 | 491 | 0.67 | 0.78 | 54 | empty |
| 3 | 416 | 0.60 | 0.76 | 35 | empty |
| 4 | 398 | 0.59 | 0.76 | 49 | empty |
| 5 | 399 | 0.59 | 0.76 | 48 | empty |
Interfaces
2 interfaces between chains.
- A–B · 2161 Ų buried · 41 hydrogen bonds · protein-protein
- C–D · 2145 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9P6Q6
- Elsewhere: RCSB PDB 4PN0 · PDBe 4PN0 · UniProt Q9P6Q6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.