MolNFT v1 · #103620 · protein
Structure of a putative periplasmic iron siderophore binding protein (RV0265C) from mycobacterium tuberculosis H37RV
4PM4 · Iron complex transporter substrate-binding protein: “Structure of a putative periplasmic iron siderophore binding protein (RV0265C) from mycobacterium…”. X-ray diffraction, 2 ligands (CL, SO4), 4 pockets (best druggability 0.75).…
- PDB
- 4PM4
- Type
- protein
- Length
- 579 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Iron complex transporter substrate-binding protein
- UniProt
- L7N6B2
- Ligands
- CL, SO4
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Iron complex transporter substrate-binding protein | protein | 290 | 44% helix, 19% strand | L7N6B2 |
| B | Iron complex transporter substrate-binding protein | protein | 289 | 45% helix, 18% strand | L7N6B2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 673 | 0.75 | 0.81 | 64 | empty |
| 2 | 346 | 0.65 | 0.80 | 47 | empty |
| 3 | 201 | 0.61 | 0.82 | 24 | empty |
| 4 | 244 | 0.57 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 925 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4PM4 · Structure of a putative periplasmic iron siderophore binding protein (Rv0265c) from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt L7N6B2
- Elsewhere: RCSB PDB 4PM4 · PDBe 4PM4 · UniProt L7N6B2
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