MolNFT v1 · #103583 · protein

X-ray crystal structure of C118A rlmn from escherichia COLI

4PL2 · Dual-specificity RNA methyltransferase rlmn: “X-ray crystal structure of C118A rlmn from escherichia COLI”. X-ray diffraction, 1 ligand (SF4), 4 pockets (best druggability 0.82). MolNFT v1 #103583 on GenesisL1: 3D structure, binding…

PDB: 4PL2
Type: protein
Length: 700 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dual-specificity RNA methyltransferase rlmn
EC: 2.1.1.192
UniProt: C9QPQ6
Ligands: SF4
Pockets: 4 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	Dual-specificity RNA methyltransferase rlmn (EC 2.1.1.192)	protein	350	43% helix, 20% strand	C9QPQ6

Ligands and binding sites

SF4 · Iron/sulfur cluster · ligand · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	958	0.82	0.83	63	SF4
2	1065	0.80	0.82	78	SF4
3	72	0.38	0.78	18	empty
4	71	0.29	0.72	12	empty

Compared structures

4PL2 · X-ray crystal structure of C118A RlmN from Escherichia coli · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C9QPQ6
Elsewhere: RCSB PDB 4PL2 · PDBe 4PL2 · UniProt C9QPQ6

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