MolNFT v1 · #103535 · protein
Myosin VI motor domain in the pi release state, space group P212121 - soaked with PO4 - located in the active site
4PJM · Unconventional myosin-VI: “Myosin VI motor domain in the pi release state, space group P212121 - soaked with PO4 - located in the active…”. X-ray diffraction, 3 ligands (ADP, MG, PO4), 5 pockets (best druggability 0.82). MolNFT v1…
- PDB
- 4PJM
- Type
- protein
- Length
- 753 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unconventional myosin-VI
- UniProt
- F1RQI7
- Ligands
- ADP, MG, PO4
- Pockets
- 5 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-VI | protein | 753 | 48% helix, 16% strand | F1RQI7 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
- GOL · Glycerol · additive · 7 copies · chains A
- IPA · Isopropyl alcohol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1128 | 0.82 | 0.83 | 117 | PO4, MG, ADP, GOL |
| 2 | 445 | 0.72 | 0.82 | 44 | empty |
| 3 | 229 | 0.66 | 0.84 | 31 | IPA |
| 4 | 145 | 0.60 | 0.84 | 31 | GOL |
| 5 | 60 | 0.31 | 0.75 | 16 | empty |
Compared structures
- 4PJM · Myosin VI motor domain in the Pi release state, space group P212121 - soaked with PO4… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F1RQI7
- Elsewhere: RCSB PDB 4PJM · PDBe 4PJM · UniProt F1RQI7
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