MolNFT v1 · #103447 · protein
Capsid protein from bovine leukemia virus
4PH0 · Blv capsid: “Capsid protein from bovine leukemia virus”. X-ray diffraction, 15 pockets (best druggability 0.73). MolNFT v1 #103447 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4PH0
- Type
- protein
- Length
- 1,178 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Blv capsid
- UniProt
- A7KWZ1
- Pockets
- 15 · best druggability 0.73
Structure
x-ray diffraction · 6 distinct chains · 62% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Blv capsid | protein | 201 | 62% helix, 3% strand | A7KWZ1 |
| B | Blv capsid | protein | 188 | 63% helix, 2% strand | A7KWZ1 |
| C | Blv capsid | protein | 199 | 64% helix, 2% strand | A7KWZ1 |
| D | Blv capsid | protein | 198 | 61% helix, 4% strand | A7KWZ1 |
| E | Blv capsid | protein | 193 | 64% helix, 2% strand | A7KWZ1 |
| F | Blv capsid | protein | 199 | 60% helix, 0% strand | A7KWZ1 |
Pockets
15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 660 | 0.73 | 0.79 | 84 | empty |
| 2 | 711 | 0.71 | 0.77 | 78 | empty |
| 3 | 471 | 0.64 | 0.77 | 48 | empty |
| 4 | 451 | 0.63 | 0.77 | 48 | empty |
| 5 | 447 | 0.63 | 0.77 | 43 | empty |
Interfaces
6 interfaces between chains.
- A–F · 881 Ų buried · 11 hydrogen bonds · protein-protein
- E–F · 813 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 808 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 792 Ų buried · 8 hydrogen bonds · protein-protein
- D–E · 748 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 4PH0 · capsid protein from bovine leukemia virus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7KWZ1
- Elsewhere: RCSB PDB 4PH0 · PDBe 4PH0 · UniProt A7KWZ1
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