MolNFT v1 · #103430 · protein
Human heavy-chain domain antibody in complex with hen egg-white lysozyme
4PGJ · Human heavy chain domain antibody: “Human heavy-chain domain antibody in complex with hen egg-white lysozyme”. X-ray diffraction, 1 pocket (best druggability 0.48). MolNFT v1 #103430 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4PGJ
- Type
- protein
- Length
- 483 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human heavy chain domain antibody; Lysozyme C
- EC
- 3.2.1.17
- UniProt
- P00698
- Pockets
- 1 · best druggability 0.48
Structure
x-ray diffraction · 4 distinct chains · 24% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Human heavy chain domain antibody | protein | 119 | 3% helix, 50% strand | — |
| B | Lysozyme C (EC 3.2.1.17) | protein | 127 | 43% helix, 11% strand | P00698 |
| C | Human heavy chain domain antibody | protein | 109 | 3% helix, 49% strand | — |
| D | Lysozyme C (EC 3.2.1.17) | protein | 128 | 41% helix, 11% strand | P00698 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.48 | 0.77 | 21 | empty |
Interfaces
3 interfaces between chains.
- C–D · 799 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 796 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 261 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 4PGJ · Human heavy-chain domain antibody in complex with hen egg-white lysozyme · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00698
- Elsewhere: RCSB PDB 4PGJ · PDBe 4PGJ · UniProt P00698
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