MolNFT v1 · #103421 · protein
Glutaminase-asparaginase from pseudomonas 7A
4PGA: “Glutaminase-asparaginase from pseudomonas 7A”. X-ray diffraction, 2 ligands (SO4, NH4), 9 pockets (best druggability 0.68). MolNFT v1 #103421 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4PGA
- Type
- protein
- Length
- 660 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaminase-asparaginase
- EC
- 3.5.1.38
- UniProt
- P10182
- Ligands
- SO4, NH4
- Pockets
- 9 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutaminase-asparaginase (EC 3.5.1.38) | protein | 330 | 32% helix, 22% strand | P10182 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.68 | 0.98 | 19 | empty |
| 2 | 60 | 0.68 | 0.96 | 24 | empty |
| 3 | 59 | 0.63 | 0.93 | 23 | empty |
| 4 | 103 | 0.59 | 0.87 | 26 | SO4, NH4 |
| 5 | 117 | 0.57 | 0.84 | 32 | SO4, NH4 |
Interfaces
1 interface between chains.
- A–B · 2439 Ų buried · 39 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10182
- Elsewhere: RCSB PDB 4PGA · PDBe 4PGA · UniProt P10182
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