MolNFT v1 · #103370 · protein
Structure of gallus gallus ribonuclease inhibitor complexed with gallus gallus ribonuclease I
4PER: “Structure of gallus gallus ribonuclease inhibitor complexed with gallus gallus ribonuclease I”. X-ray diffraction, 5 pockets (best druggability 0.76). MolNFT v1 #103370 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4PER
- Type
- protein
- Length
- 567 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonuclease inhibitor; Angiogenin
- EC
- 3.1.27.-
- UniProt
- Q5ZIY8, P27043
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribonuclease inhibitor | protein | 458 | 41% helix, 14% strand | Q5ZIY8 |
| B | Angiogenin (EC 3.1.27.-) | protein | 109 | 22% helix, 35% strand | P27043 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 553 | 0.76 | 0.83 | 58 | empty |
| 2 | 212 | 0.59 | 0.80 | 35 | empty |
| 3 | 223 | 0.56 | 0.79 | 28 | empty |
| 4 | 109 | 0.49 | 0.80 | 21 | empty |
| 5 | 51 | 0.27 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1482 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4PER · Structure of Gallus gallus ribonuclease inhibitor complexed with Gallus gallus… · the same entry in another collection · chain A against A, TM-score 1.00
- P27043 · AlphaFold monomer V2.0 prediction for angiogenin (P27043) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ZIY8
- Every structure of UniProt P27043
- Elsewhere: RCSB PDB 4PER · PDBe 4PER · UniProt Q5ZIY8 · UniProt P27043
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