MolNFT v1 · #103289 · protein

Structure-based protein engineering efforts on the scaffold of a monomeric triosephosphate isomerase yielding a sugar isomerase

4PC8 · MA21-tim: “Structure-based protein engineering efforts on the scaffold of a monomeric triosephosphate isomerase yielding…”. X-ray diffraction, 1 ligand (GOA), 1 pocket (best druggability 0.52). MolNFT v1 #103289 on GenesisL1: 3D…

PDB: 4PC8
Type: protein
Length: 239 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MA21-tim
EC: 5.3.1.1
Ligands: GOA
Pockets: 1 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MA21-tim (EC 5.3.1.1)	protein	239	49% helix, 18% strand	—

Ligands and binding sites

GOA · Glycolic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	187	0.52	0.78	29	GOA

Compared structures

4PC8 · Structure-based protein engineering efforts on the scaffold of a monomeric… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4PC8 · PDBe 4PC8

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