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MolNFT v1 · #103250 · protein

Structure of hypothetical protein HP1257.

4PAW · Orotate phosphoribosyltransferase: “Structure of hypothetical protein HP1257.”. X-ray diffraction, 3 ligands (ZN, PO4, SCN), 2 pockets (best druggability 0.65). MolNFT v1 #103250 on GenesisL1: 3D structure, binding sites and pockets…

PDB
4PAW
Type
protein
Length
393 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Orotate phosphoribosyltransferase
EC
2.4.2.10
UniProt
P56162
Ligands
ZN, PO4, SCN
Pockets
2 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 29% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AOrotate phosphoribosyltransferase (EC 2.4.2.10)protein19730% helix, 29% strandP56162
BOrotate phosphoribosyltransferase (EC 2.4.2.10)protein19629% helix, 29% strandP56162

Ligands and binding sites

  • ZN · Zinc ion · metal · 2 copies · chains A, B
  • PO4 · Phosphate ion · ion · 2 copies · chains A, B
  • SCN · Thiocyanate ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
14200.650.7845PO4
22720.520.7537PO4

Interfaces

1 interface between chains.

  • A–B · 1234 Ų buried · 18 hydrogen bonds · protein-protein

Compared structures

  • 4PAW · Structure of hypothetical protein HP1257. · the same entry in another collection · chain A against A, TM-score 1.00
  • P56162 · AlphaFold monomer V2.0 prediction for orotate phosphoribosyltransferase (P56162) · a predicted model of the same protein · chain B against A, TM-score 0.95

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