MolNFT v1 · #103216 · protein + DNA
Fadr, fatty acid responsive transcription factor from vibrio cholerae, in complex with DNA
4P9U · Fatty acid metabolism regulator protein: “Fadr, fatty acid responsive transcription factor from vibrio cholerae, in complex with DNA”. X-ray diffraction, 20 pockets (best druggability 0.76). MolNFT v1 #103216 on GenesisL1: 3D…
- PDB
- 4P9U
- Type
- protein + DNA
- Length
- 1,212 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty acid metabolism regulator protein; DNA (31-mer)
- UniProt
- Q9KQU8
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 63% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, F, A, B | Fatty acid metabolism regulator protein | protein | 272 | 63% helix, 2% strand | Q9KQU8 |
| G, C | DNA (31-mer) | dna | 31 | — | — |
| H, D | DNA (31-mer) | dna | 31 | — | — |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 772 | 0.76 | 0.81 | 78 | empty |
| 2 | 537 | 0.73 | 0.82 | 71 | empty |
| 3 | 152 | 0.59 | 0.83 | 26 | empty |
| 4 | 139 | 0.52 | 0.80 | 25 | empty |
| 5 | 295 | 0.51 | 0.74 | 38 | empty |
Interfaces
17 interfaces between chains.
- A–B · 1746 Ų buried · 28 hydrogen bonds · protein-protein
- E–F · 1725 Ų buried · 26 hydrogen bonds · protein-protein
- G–H · 1377 Ų buried · 141 hydrogen bonds · nucleic-nucleic
- C–D · 1371 Ų buried · 140 hydrogen bonds · nucleic-nucleic
- B–D · 512 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 4P9U · FadR, Fatty Acid Responsive Transcription Factor from Vibrio cholerae, in Complex with DNA · the same entry in another collection · chain D against D, TM-score 1.00
- Q9KQU8 · AlphaFold monomer V2.0 prediction for fatty acid metabolism regulator protein (Q9KQU8) · a predicted model of the same protein · chain E against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KQU8
- Elsewhere: RCSB PDB 4P9U · PDBe 4P9U · UniProt Q9KQU8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.