MolNFT v1 · #103096 · protein
Structure of the N-terminal domain of the human mitochondrial ASPARTATE/GLUTAMATE carrier aralar in the apo state
4P60 · Calcium-binding mitochondrial carrier protein ARALAR1: “Structure of the N-terminal domain of the human mitochondrial ASPARTATE/GLUTAMATE carrier aralar in the apo…”. X-ray diffraction, 1 ligand (NA), 8 pockets (best druggability…
- PDB
- 4P60
- Type
- protein
- Length
- 523 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium-binding mitochondrial carrier protein ARALAR1
- UniProt
- O75746
- Ligands
- NA
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium-binding mitochondrial carrier protein ARALAR1 | protein | 239 | 62% helix, 4% strand | O75746 |
| B | Calcium-binding mitochondrial carrier protein ARALAR1 | protein | 284 | 56% helix, 6% strand | O75746 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 890 | 0.82 | 0.84 | 66 | empty |
| 2 | 89 | 0.41 | 0.78 | 21 | empty |
| 3 | 84 | 0.39 | 0.77 | 14 | empty |
| 4 | 100 | 0.35 | 0.74 | 18 | empty |
| 5 | 62 | 0.34 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2078 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 4P60 · Structure of the N-terminal domain of the human mitochondrial aspartate/glutamate carrier… · the same entry in another collection · chain A against A, TM-score 1.00
- O75746 · AlphaFold monomer V2.0 prediction for calcium-binding mitochondrial carrier protein… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75746
- Elsewhere: RCSB PDB 4P60 · PDBe 4P60 · UniProt O75746
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