MolNFT v1 · #102936 · protein
Native structure of the P domain from a GI.7 norovirus variant.
4P12 · Major capsid protein: “Native structure of the P domain from a GI.7 norovirus variant.”. X-ray diffraction, 9 pockets (best druggability 0.79). MolNFT v1 #102936 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4P12
- Type
- protein
- Length
- 1,169 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major capsid protein
- UniProt
- G8FL04
- Pockets
- 9 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 7% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major capsid protein | protein | 296 | 6% helix, 33% strand | G8FL04 |
| B | Major capsid protein | protein | 288 | 9% helix, 33% strand | G8FL04 |
| C | Major capsid protein | protein | 295 | 7% helix, 32% strand | G8FL04 |
| D | Major capsid protein | protein | 290 | 7% helix, 34% strand | G8FL04 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 564 | 0.79 | 0.85 | 74 | empty |
| 2 | 544 | 0.79 | 0.86 | 73 | empty |
| 3 | 102 | 0.57 | 0.85 | 29 | empty |
| 4 | 265 | 0.56 | 0.77 | 38 | empty |
| 5 | 124 | 0.54 | 0.82 | 34 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1626 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 1547 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 450 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4P12 · Native Structure of the P domain from a GI.7 Norovirus variant. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G8FL04
- Elsewhere: RCSB PDB 4P12 · PDBe 4P12 · UniProt G8FL04
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