MolNFT v1 · #102890 · protein

Crystal structure of the ligand binding domains of the bovicola ovis ecdysone receptor ECR/USP heterodimer (methylene lactam crystal)

4OZR: “Crystal structure of the ligand binding domains of the bovicola ovis ecdysone receptor ECR/USP heterodimer…”. X-ray diffraction, 8 pockets (best druggability 0.70). MolNFT v1 #102890 on GenesisL1: 3D structure, binding sites and…

PDB: 4OZR
Type: protein
Length: 393 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ecdysone receptor; Retinoid X receptor
UniProt: E0VVT4, E0VFQ5
Pockets: 8 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 65% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Ecdysone receptor	protein	197	64% helix, 0% strand	E0VVT4
U	Retinoid X receptor	protein	196	65% helix, 3% strand	E0VFQ5

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	244	0.70	0.85	26	empty
2	54	0.69	0.97	13	empty
3	547	0.64	0.76	55	empty
4	214	0.58	0.80	37	empty
5	74	0.38	0.78	17	empty

Interfaces

1 interface between chains.

E–U · 1145 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

4OZR · Crystal structure of the ligand binding domains of the Bovicola ovis ecdysone receptor… · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E0VVT4
Every structure of UniProt E0VFQ5
Elsewhere: RCSB PDB 4OZR · PDBe 4OZR · UniProt E0VVT4 · UniProt E0VFQ5

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