MolNFT v1 · #102690 · protein

Crystal structure of PRK1 catalytic domain

4OTD · SERINE/THREONINE-protein kinase N1: “Crystal structure of PRK1 catalytic domain”. X-ray diffraction, 2 pockets (best druggability 0.70). MolNFT v1 #102690 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4OTD
Type: protein
Length: 336 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase N1
EC: 2.7.11.13
UniProt: Q16512
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase N1 (EC 2.7.11.13)	protein	336	36% helix, 15% strand	Q16512

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	449	0.70	0.81	54	empty
2	64	0.28	0.73	17	empty

Modifications

Observed in the structure: 2 modified (phosphorylation).

Compared structures

4OTD · Crystal Structure of PRK1 Catalytic Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q16512 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase N1 (Q16512) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16512
Elsewhere: RCSB PDB 4OTD · PDBe 4OTD · UniProt Q16512

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.