MolNFT v1 · #102661 · protein + DNA
Crystal structure of tal effector reveals the recognition between asparagine and guanine
4OSK · HAX3: “Crystal structure of tal effector reveals the recognition between asparagine and guanine”. X-ray diffraction, 8 pockets (best druggability 0.78). MolNFT v1 #102661 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4OSK
- Type
- protein + DNA
- Length
- 1,048 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HAX3; DNA (5'- D(*TP*GP*TP*CP*CP*AP*AP*CP*TP*AP*CP*TP*AP*GP*AP*CP*T)-3'); DNA (5'…
- UniProt
- Q3ZD72
- Pockets
- 8 · best druggability 0.78
Structure
x-ray diffraction · 5 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HAX3 | protein | 490 | 75% helix, 0% strand | Q3ZD72 |
| I | DNA (5'- D(*TP*GP*TP*CP*CP*AP*AP*CP*TP*AP*CP*TP*AP*GP*AP*CP*T)-3') | dna | 17 | — | — |
| J, H | DNA (5'- D(*AP*GP*TP*CP*TP*AP*GP*TP*AP*GP*TP*TP*GP*GP*AP*CP*A)-3') | dna | 17 | — | — |
| B | HAX3 | protein | 491 | 73% helix, 0% strand | Q3ZD72 |
| G | DNA (5'- D(*TP*GP*TP*CP*CP*AP*AP*CP*TP*AP*CP*TP*AP*GP*AP*CP*T)-3') | dna | 16 | — | — |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 927 | 0.78 | 0.81 | 94 | empty |
| 2 | 1072 | 0.77 | 0.80 | 96 | empty |
| 3 | 210 | 0.42 | 0.73 | 20 | empty |
| 4 | 123 | 0.36 | 0.73 | 20 | empty |
| 5 | 92 | 0.35 | 0.75 | 19 | empty |
Interfaces
10 interfaces between chains.
- B–G · 1849 Ų buried · 31 hydrogen bonds · protein-nucleic
- A–I · 1734 Ų buried · 28 hydrogen bonds · protein-nucleic
- I–J · 755 Ų buried · 65 hydrogen bonds · nucleic-nucleic
- G–H · 715 Ų buried · 68 hydrogen bonds · nucleic-nucleic
- A–B · 650 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4OSK · Crystal structure of TAL effector reveals the recognition between asparagine and guanine · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3ZD72
- Elsewhere: RCSB PDB 4OSK · PDBe 4OSK · UniProt Q3ZD72
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