MolNFT v1 · #102621 · protein
Crystal structure of marburg virus VP24
4OR8 · Membrane-associated protein VP24: “Crystal structure of marburg virus VP24”. X-ray diffraction, 4 pockets (best druggability 0.79). MolNFT v1 #102621 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4OR8
- Type
- protein
- Length
- 451 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Membrane-associated protein VP24
- UniProt
- P35256
- Pockets
- 4 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Membrane-associated protein VP24 | protein | 225 | 34% helix, 24% strand | P35256 |
| B | Membrane-associated protein VP24 | protein | 226 | 36% helix, 26% strand | P35256 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 221 | 0.79 | 0.93 | 47 | empty |
| 2 | 355 | 0.63 | 0.79 | 51 | empty |
| 3 | 66 | 0.38 | 0.78 | 14 | empty |
| 4 | 75 | 0.37 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 3130 Ų buried · 56 hydrogen bonds · protein-protein
Compared structures
- 4OR8 · Crystal structure of Marburg virus VP24 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35256
- Elsewhere: RCSB PDB 4OR8 · PDBe 4OR8 · UniProt P35256
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