MolNFT v1 · #10256 · protein
Interleukin-10 crystal structure reveals the functional dimer with an unexpected topological similarity to interferon gamma
1ILK: “Interleukin-10 crystal structure reveals the functional dimer with an unexpected topological similarity to…”. X-ray diffraction, 1 pocket (best druggability 0.55). MolNFT v1 #10256 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1ILK
- Type
- protein
- Length
- 151 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-10
- UniProt
- P22301
- Pockets
- 1 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-10 | protein | 151 | 75% helix, 0% strand | P22301 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 327 | 0.55 | 0.74 | 29 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1ILK · Interleukin-10 crystal structure reveals the functional dimer with an unexpected… · the same entry in another collection · chain A against A, TM-score 1.00
- P22301 · AlphaFold monomer V2.0 prediction for interleukin-10 (P22301) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22301
- Elsewhere: RCSB PDB 1ILK · PDBe 1ILK · UniProt P22301
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