MolNFT v1 · #10254 · protein
Crystal structure of apo human pregnane X receptor ligand binding domain
1ILG · Orphan nuclear receptor pxr: “Crystal structure of apo human pregnane X receptor ligand binding domain”. X-ray diffraction, 4 pockets (best druggability 0.86). MolNFT v1 #10254 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1ILG
- Type
- protein
- Length
- 270 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Orphan nuclear receptor pxr
- UniProt
- O75469
- Pockets
- 4 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Orphan nuclear receptor pxr | protein | 270 | 56% helix, 8% strand | O75469 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 430 | 0.86 | 0.93 | 44 | empty |
| 2 | 142 | 0.48 | 0.78 | 18 | empty |
| 3 | 69 | 0.34 | 0.76 | 15 | empty |
| 4 | 51 | 0.29 | 0.75 | 14 | empty |
Compared structures
- 1ILG · Crystal Structure of Apo Human Pregnane X Receptor Ligand Binding Domain · the same entry in another collection · chain A against A, TM-score 1.00
- O75469 · AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 1 group I member 2… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75469
- Elsewhere: RCSB PDB 1ILG · PDBe 1ILG · UniProt O75469
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