MolNFT v1 · #102398 · protein

Crystal structure of RNase as from M tuberculosis

4OKJ · 3'-5' exoribonuclease RV2179C/MT2234.1: “Crystal structure of RNase as from M tuberculosis”. X-ray diffraction, 1 ligand (MG), 3 pockets (best druggability 0.61). MolNFT v1 #102398 on GenesisL1: 3D structure, binding sites and…

PDB: 4OKJ
Type: protein
Length: 318 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3'-5' exoribonuclease RV2179C/MT2234.1
EC: 3.1.13.-
UniProt: L7N5T0
Ligands: MG
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3'-5' exoribonuclease RV2179C/MT2234.1 (EC 3.1.13.-)	protein	160	38% helix, 21% strand	L7N5T0
B	3'-5' exoribonuclease RV2179C/MT2234.1 (EC 3.1.13.-)	protein	158	35% helix, 22% strand	L7N5T0

Ligands and binding sites

MG · Magnesium ion · metal · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	383	0.61	0.76	38	MG
2	281	0.56	0.76	33	MG
3	119	0.44	0.77	23	empty

Interfaces

1 interface between chains.

A–B · 1272 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

4OKJ · Crystal structure of RNase AS from M tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt L7N5T0
Elsewhere: RCSB PDB 4OKJ · PDBe 4OKJ · UniProt L7N5T0

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