MolNFT v1 · #102325 · protein
Structural and kinetic bases for the metal preference of the M18 aminopeptidase from pseudomonas aeruginosa
4OID · Probable M18 family aminopeptidase 2: “Structural and kinetic bases for the metal preference of the M18 aminopeptidase from pseudomonas aeruginosa”. X-ray diffraction, 14 pockets (best druggability 0.78). MolNFT v1 #102325 on…
- PDB
- 4OID
- Type
- protein
- Length
- 1,628 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable M18 family aminopeptidase 2
- EC
- 3.4.11.-
- UniProt
- Q9HYZ3
- Pockets
- 14 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Probable M18 family aminopeptidase 2 (EC 3.4.11.-) | protein | 407 | 29% helix, 30% strand | Q9HYZ3 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.78 | 0.99 | 28 | empty |
| 2 | 81 | 0.76 | 0.98 | 23 | empty |
| 3 | 50 | 0.72 | 0.99 | 25 | empty |
| 4 | 505 | 0.64 | 0.76 | 50 | empty |
| 5 | 469 | 0.64 | 0.77 | 54 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3362 Ų buried · 62 hydrogen bonds · protein-protein
- C–D · 3321 Ų buried · 62 hydrogen bonds · protein-protein
- A–C · 79 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4OID · Structural and kinetic bases for the metal preference of the M18 aminopeptidase from… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9HYZ3 · AlphaFold monomer V2.0 prediction for probable M18 family aminopeptidase 2 (Q9HYZ3) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HYZ3
- Elsewhere: RCSB PDB 4OID · PDBe 4OID · UniProt Q9HYZ3
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