MolNFT v1 · #102305 · protein
Crystal structure of succinic semialdehyde dehydrogenase from streptococcus pyogenes in complex with NADP+ as the cofactor
4OHT · Succinate-semialdehyde dehydrogenase: “Crystal structure of succinic semialdehyde dehydrogenase from streptococcus pyogenes in complex with NADP+ as…”. X-ray diffraction, 1 ligand (NAP), 7 pockets (best druggability 0.83). MolNFT v1…
- PDB
- 4OHT
- Type
- protein
- Length
- 910 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Succinate-semialdehyde dehydrogenase
- UniProt
- H8HE26
- Ligands
- NAP
- Pockets
- 7 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Succinate-semialdehyde dehydrogenase | protein | 455 | 43% helix, 21% strand | H8HE26 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 975 | 0.83 | 0.84 | 108 | empty |
| 2 | 448 | 0.65 | 0.78 | 40 | NAP |
| 3 | 437 | 0.63 | 0.77 | 47 | NAP |
| 4 | 257 | 0.54 | 0.77 | 28 | empty |
| 5 | 186 | 0.53 | 0.78 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 2588 Ų buried · 35 hydrogen bonds · protein-protein
Compared structures
- 4OHT · Crystal structure of succinic semialdehyde dehydrogenase from Streptococcus pyogenes in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H8HE26
- Elsewhere: RCSB PDB 4OHT · PDBe 4OHT · UniProt H8HE26
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