MolNFT v1 · #102185 · protein

Structure of membrane binding protein pleurotolysin a from pleurotus ostreatus

4OEB: “Structure of membrane binding protein pleurotolysin a from pleurotus ostreatus”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.84). MolNFT v1 #102185 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4OEB
Type: protein
Length: 540 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pleurotolysin a
UniProt: Q8X1M9
Ligands: SO4
Pockets: 4 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 59% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Pleurotolysin a	protein	135	2% helix, 59% strand	Q8X1M9

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	940	0.84	0.86	119	empty
2	114	0.35	0.73	27	empty
3	65	0.34	0.77	17	empty
4	50	0.28	0.75	16	empty

Interfaces

5 interfaces between chains.

A–D · 564 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 555 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 531 Å² buried · 9 hydrogen bonds · protein-protein
B–D · 236 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 231 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

4OEB · Structure of membrane binding protein pleurotolysin A from Pleurotus ostreatus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8X1M9
Elsewhere: RCSB PDB 4OEB · PDBe 4OEB · UniProt Q8X1M9

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