MolNFT v1 · #102160 · protein
Crystal structure of human Fab CAP256-VRC26.UCA, a potent V1V2- directed HIV-1 neutralizing antibody
4ODH · CAP256-VRC26.UCA light chain: “Crystal structure of human Fab CAP256-VRC26.UCA, a potent V1V2- directed HIV-1 neutralizing antibody”. X-ray diffraction, 3 pockets (best druggability 0.68). MolNFT v1 #102160 on GenesisL1: 3D…
- PDB
- 4ODH
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CAP256-VRC26.UCA light chain; CAP256-VRC26.UCA heavy chain
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | CAP256-VRC26.UCA light chain | protein | 210 | 8% helix, 47% strand | — |
| H | CAP256-VRC26.UCA heavy chain | protein | 222 | 1% helix, 46% strand | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 736 | 0.68 | 0.76 | 72 | empty |
| 2 | 232 | 0.54 | 0.77 | 47 | empty |
| 3 | 53 | 0.29 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- L–H · 1784 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4ODH · Crystal structure of human Fab CAP256-VRC26.UCA, a potent V1V2-directed HIV-1… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4ODH · PDBe 4ODH
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