MolNFT v1 · #102144 · protein

Crystal structure of human Fab CAP256-VRC26.03, a potent V1V2-directed HIV-1 neutralizing antibody

4OD1 · CAP256-VRC26.03 heavy chain: “Crystal structure of human Fab CAP256-VRC26.03, a potent V1V2-directed HIV-1 neutralizing antibody”. X-ray diffraction, 4 pockets (best druggability 0.71). MolNFT v1 #102144 on GenesisL1: 3D structure…

PDB: 4OD1
Type: protein
Length: 454 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CAP256-VRC26.03 heavy chain; CAP256-VRC26.03 light chain
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	CAP256-VRC26.03 heavy chain	protein	243	6% helix, 54% strand	—
L	CAP256-VRC26.03 light chain	protein	211	6% helix, 49% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	842	0.71	0.76	71	empty
2	124	0.42	0.76	25	empty
3	91	0.37	0.76	21	empty
4	103	0.35	0.73	22	empty

Interfaces

1 interface between chains.

H–L · 1723 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide, 2 modified (disulfide, sulfation).

Compared structures

4OD1 · Crystal structure of human Fab CAP256-VRC26.03, a potent V1V2-directed HIV-1 neutralizing… · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4OD1 · PDBe 4OD1

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