MolNFT v1 · #102139 · protein

Crystal structure of human Fab CAP256-VRC26.06, a potent V1V2-directed HIV-1 neutralizing antibody

4OCW · CAP256-VRC26.06 light chain: “Crystal structure of human Fab CAP256-VRC26.06, a potent V1V2-directed HIV-1 neutralizing antibody”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #102139 on GenesisL1: 3D structure…

PDB: 4OCW
Type: protein
Length: 464 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CAP256-VRC26.06 light chain; CAP256-VRC26.06 heavy chain
Pockets: 4 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	CAP256-VRC26.06 light chain	protein	211	6% helix, 48% strand	—
H	CAP256-VRC26.06 heavy chain	protein	253	6% helix, 48% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	945	0.73	0.77	82	empty
2	206	0.47	0.74	30	empty
3	66	0.42	0.81	20	empty
4	76	0.40	0.79	20	empty

Interfaces

1 interface between chains.

L–H · 1891 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide, 2 modified (disulfide, sulfation).

Compared structures

4OCW · Crystal structure of human Fab CAP256-VRC26.06, a potent V1V2-directed HIV-1 neutralizing… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4OCW · PDBe 4OCW

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