MolNFT v1 · #102078 · protein
Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10
4OB5 · 4E10 antibody germline precursor 7 heavy chain fv: “Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10”. X-ray diffraction, 1 ligand (TMO), 4 pockets (best druggability 0.45).…
- PDB
- 4OB5
- Type
- protein
- Length
- 234 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 4E10 antibody germline precursor 7 heavy chain fv; 4E10 antibody germline precursor 7…
- Ligands
- TMO
- Pockets
- 4 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | 4E10 antibody germline precursor 7 heavy chain fv | protein | 122 | 2% helix, 52% strand | — |
| L | 4E10 antibody germline precursor 7 light chain fv | protein | 112 | 5% helix, 48% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.45 | 0.76 | 21 | empty |
| 2 | 65 | 0.30 | 0.75 | 18 | empty |
| 3 | 51 | 0.26 | 0.74 | 14 | GOL |
| 4 | 54 | 0.24 | 0.71 | 16 | empty |
Interfaces
1 interface between chains.
- H–L · 710 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4OB5 · Ontogeny of recognition specificity and functionality for the broadly neutralizing… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4OB5 · PDBe 4OB5
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