MolNFT v1 · #102056 · protein
Crystal structure of the cytosolic domain of mouse MID51 H201A mutant
4OAH · Mitochondrial dynamic protein MID51: “Crystal structure of the cytosolic domain of mouse MID51 H201A mutant”. X-ray diffraction, 1 ligand (SO4), 11 pockets (best druggability 0.76). MolNFT v1 #102056 on GenesisL1: 3D structure…
- PDB
- 4OAH
- Type
- protein
- Length
- 1,314 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial dynamic protein MID51
- UniProt
- Q8BGV8
- Ligands
- SO4
- Pockets
- 11 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 47% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Mitochondrial dynamic protein MID51 | protein | 330 | 47% helix, 18% strand | Q8BGV8 |
| B | Mitochondrial dynamic protein MID51 | protein | 327 | 48% helix, 18% strand | Q8BGV8 |
| C | Mitochondrial dynamic protein MID51 | protein | 327 | 47% helix, 18% strand | Q8BGV8 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, D, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 957 | 0.76 | 0.79 | 109 | SO4 |
| 2 | 807 | 0.73 | 0.78 | 96 | SO4 |
| 3 | 735 | 0.73 | 0.79 | 85 | SO4 |
| 4 | 771 | 0.73 | 0.78 | 91 | SO4 |
| 5 | 131 | 0.56 | 0.83 | 30 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1205 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 1079 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 424 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4OAH · Crystal structure of the cytosolic domain of mouse MiD51 H201A mutant · the same entry in another collection · chain A against A, TM-score 1.00
- Q8BGV8 · AlphaFold monomer V2.0 prediction for mitochondrial dynamics protein MID51 (Q8BGV8) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BGV8
- Elsewhere: RCSB PDB 4OAH · PDBe 4OAH · UniProt Q8BGV8
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