MolNFT v1 · #102054 · protein
Crystal structure of the cytosolic domain of mouse MID51
4OAF · Mitochondrial dynamic protein MID51: “Crystal structure of the cytosolic domain of mouse MID51”. X-ray diffraction, 11 pockets (best druggability 0.77). MolNFT v1 #102054 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4OAF
- Type
- protein
- Length
- 1,306 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial dynamic protein MID51
- UniProt
- Q8BGV8
- Pockets
- 11 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 47% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial dynamic protein MID51 | protein | 326 | 48% helix, 18% strand | Q8BGV8 |
| B | Mitochondrial dynamic protein MID51 | protein | 327 | 47% helix, 17% strand | Q8BGV8 |
| C | Mitochondrial dynamic protein MID51 | protein | 326 | 48% helix, 18% strand | Q8BGV8 |
| D | Mitochondrial dynamic protein MID51 | protein | 327 | 46% helix, 18% strand | Q8BGV8 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 771 | 0.77 | 0.81 | 102 | empty |
| 2 | 751 | 0.76 | 0.80 | 76 | empty |
| 3 | 554 | 0.74 | 0.82 | 65 | empty |
| 4 | 573 | 0.74 | 0.81 | 73 | empty |
| 5 | 53 | 0.58 | 0.91 | 20 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1225 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 1140 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 401 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 4OAF · Crystal structure of the cytosolic domain of mouse MiD51 · the same entry in another collection · chain D against D, TM-score 1.00
- Q8BGV8 · AlphaFold monomer V2.0 prediction for mitochondrial dynamics protein MID51 (Q8BGV8) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BGV8
- Elsewhere: RCSB PDB 4OAF · PDBe 4OAF · UniProt Q8BGV8
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