MolNFT v1 · #102050 · protein
X-ray crystal structure of O-methyltransferase from anaplasma phagocytophilum in apo form
4OA8 · O-methyltransferase family protein: “X-ray crystal structure of O-methyltransferase from anaplasma phagocytophilum in apo form”. X-ray diffraction, 1 ligand (NA), 4 pockets (best druggability 0.52). MolNFT v1 #102050 on GenesisL1…
- PDB
- 4OA8
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- O-methyltransferase family protein
- EC
- 2.1.1.-
- UniProt
- Q2GKC7
- Ligands
- NA
- Pockets
- 4 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | O-methyltransferase family protein (EC 2.1.1.-) | protein | 214 | 47% helix, 20% strand | Q2GKC7 |
| B | O-methyltransferase family protein (EC 2.1.1.-) | protein | 213 | 46% helix, 20% strand | Q2GKC7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 222 | 0.52 | 0.77 | 41 | NA |
| 2 | 182 | 0.49 | 0.77 | 42 | NA |
| 3 | 76 | 0.37 | 0.77 | 13 | empty |
| 4 | 62 | 0.31 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1786 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4OA8 · X-ray crystal structure of O-methyltransferase from Anaplasma phagocytophilum in apo form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2GKC7
- Elsewhere: RCSB PDB 4OA8 · PDBe 4OA8 · UniProt Q2GKC7
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