MolNFT v1 · #101964 · protein

Crystal structure of a glutathione S-transferase from rhodospirillum rubrum F11, target efi-507460

4O7H: “Crystal structure of a glutathione S-transferase from rhodospirillum rubrum F11, target efi-507460”. X-ray diffraction, 3 pockets (best druggability 0.80). MolNFT v1 #101964 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4O7H
Type: protein
Length: 442 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutathione S-transferase
EC: 2.5.1.18
UniProt: G2TFN6
Pockets: 3 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutathione S-transferase (EC 2.5.1.18)	protein	222	56% helix, 8% strand	G2TFN6
B	Glutathione S-transferase (EC 2.5.1.18)	protein	220	57% helix, 8% strand	G2TFN6

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	934	0.80	0.82	68	empty
2	64	0.45	0.83	16	empty
3	63	0.44	0.82	18	empty

Interfaces

1 interface between chains.

A–B · 1222 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

4O7H · Crystal structure of a glutathione S-transferase from Rhodospirillum rubrum F11, Target… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G2TFN6
Elsewhere: RCSB PDB 4O7H · PDBe 4O7H · UniProt G2TFN6

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