MolNFT v1 · #101936 · protein

Structural and functional studies the characterization of CYS4 zinc- finger motif in the recombination mediator protein recr

4O6O · Recombination protein recr: “Structural and functional studies the characterization of CYS4 zinc- finger motif in the recombination…”. X-ray diffraction, 1 ligand (ZN), 11 pockets (best druggability 0.58). MolNFT v1 #101936 on…

PDB: 4O6O
Type: protein
Length: 790 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Recombination protein recr
UniProt: Q8RDI4
Ligands: ZN
Pockets: 11 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Recombination protein recr	protein	197	42% helix, 11% strand	Q8RDI4
D	Recombination protein recr	protein	199	38% helix, 11% strand	Q8RDI4

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
IMD · Imidazole · additive · 3 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	349	0.58	0.76	29	empty
2	292	0.55	0.75	33	empty
3	62	0.49	0.85	19	empty
4	173	0.47	0.76	33	empty
5	110	0.45	0.78	22	empty

Interfaces

6 interfaces between chains.

A–D · 2227 Å² buried · 6 hydrogen bonds · protein-protein
C–D · 2221 Å² buried · 23 hydrogen bonds · protein-protein
B–C · 2208 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 2099 Å² buried · 25 hydrogen bonds · protein-protein
A–C · 186 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4O6O · Structural and functional studies the characterization of Cys4 Zinc-finger motif in the… · the same entry in another collection · chain A against A, TM-score 1.00
Q8RDI4 · AlphaFold monomer V2.0 prediction for recombination protein recr (Q8RDI4) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8RDI4
Elsewhere: RCSB PDB 4O6O · PDBe 4O6O · UniProt Q8RDI4

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