MolNFT v1 · #101753 · protein
Crystal structures of human kinase aurora a
4O0W · Aurora kinase a: “Crystal structures of human kinase aurora a”. X-ray diffraction, 1 ligand (ADN), 3 pockets (best druggability 0.71). MolNFT v1 #101753 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4O0W
- Type
- protein
- Length
- 259 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aurora kinase a
- EC
- 2.7.11.1
- UniProt
- O14965
- Ligands
- ADN
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aurora kinase a (EC 2.7.11.1) | protein | 259 | 41% helix, 19% strand | O14965 |
Ligands and binding sites
- ADN · Adenosine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 515 | 0.71 | 0.80 | 41 | ADN |
| 2 | 63 | 0.35 | 0.77 | 14 | empty |
| 3 | 66 | 0.34 | 0.77 | 12 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14965
- Elsewhere: RCSB PDB 4O0W · PDBe 4O0W · UniProt O14965
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