MolNFT v1 · #10175 · protein

Chicken plasma retinol-binding protein (rbp)

1IIU: “Chicken plasma retinol-binding protein (rbp)”. X-ray diffraction, 2 ligands (RTL, CD), 2 pockets (best druggability 0.82). MolNFT v1 #10175 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1IIU
Type: protein
Length: 174 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasma retinol-binding protein
UniProt: P41263
Ligands: RTL, CD
Pockets: 2 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Plasma retinol-binding protein	protein	174	11% helix, 47% strand	P41263

Ligands and binding sites

RTL · Retinol · ligand · chains A
CD · Cadmium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	224	0.82	0.95	28	RTL
2	72	0.30	0.73	13	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

1IIU · Chicken plasma retinol-binding protein (RBP) · the same entry in another collection · chain A against A, TM-score 1.00
P41263 · AlphaFold monomer V2.0 prediction for retinol-binding protein 4 (P41263) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41263
Elsewhere: RCSB PDB 1IIU · PDBe 1IIU · UniProt P41263

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