MolNFT v1 · #101716 · protein
Crystal structure of the primary monoclonal antibody 13PL Fab' from a multiple myeloma patient
4NZU · 13PL heavy chain: “Crystal structure of the primary monoclonal antibody 13PL Fab' from a multiple myeloma patient”. X-ray diffraction, 6 pockets (best druggability 0.61). MolNFT v1 #101716 on GenesisL1: 3D structure, binding sites…
- PDB
- 4NZU
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 13PL heavy chain; 13PL light chain
- Pockets
- 6 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | 13PL heavy chain | protein | 211 | 6% helix, 51% strand | — |
| H | 13PL light chain | protein | 223 | 7% helix, 49% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 467 | 0.61 | 0.75 | 55 | empty |
| 2 | 52 | 0.51 | 0.88 | 23 | GOL |
| 3 | 124 | 0.41 | 0.76 | 21 | empty |
| 4 | 89 | 0.36 | 0.75 | 19 | empty |
| 5 | 83 | 0.33 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- L–H · 1794 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 4NZU · Crystal structure of the primary monoclonal antibody 13PL Fab' from a multiple myeloma… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4NZU · PDBe 4NZU
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