MolNFT v1 · #101715 · protein
Crystal structure of the antibody-binding region of protein M (protein M td) in complex with anti-infleunza hemagglutinin antibody CR9114 Fab
4NZT: “Crystal structure of the antibody-binding region of protein M (protein M td) in complex with anti-infleunza…”. X-ray diffraction, 11 pockets (best druggability 0.83). MolNFT v1 #101715 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4NZT
- Type
- protein
- Length
- 809 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein M td; CR9114 heavy chain; CR9114 light chain
- UniProt
- P47523
- Pockets
- 11 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 13% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | Protein M td | protein | 375 | 20% helix, 29% strand | P47523 |
| H | CR9114 heavy chain | protein | 222 | 8% helix, 51% strand | — |
| L | CR9114 light chain | protein | 212 | 6% helix, 49% strand | — |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1047 | 0.83 | 0.84 | 79 | empty |
| 2 | 169 | 0.66 | 0.86 | 25 | empty |
| 3 | 283 | 0.64 | 0.81 | 43 | empty |
| 4 | 158 | 0.48 | 0.78 | 18 | empty |
| 5 | 137 | 0.46 | 0.77 | 16 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1651 Ų buried · 12 hydrogen bonds · protein-protein
- M–L · 1611 Ų buried · 22 hydrogen bonds · protein-protein
- M–H · 265 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4NZT · Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex… · the same entry in another collection · chain M against M, TM-score 1.00
- P47523 · AlphaFold monomer V2.0 prediction for uncharacterized protein MG281 (P47523) · a predicted model of the same protein · chain M against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47523
- Elsewhere: RCSB PDB 4NZT · PDBe 4NZT · UniProt P47523
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