MolNFT v1 · #101653 · protein
Crystal structure of ferm domain of human focal adhesion kinase
4NY0 · Focal adhesion kinase 1: “Crystal structure of ferm domain of human focal adhesion kinase”. X-ray diffraction, 11 pockets (best druggability 0.71). MolNFT v1 #101653 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4NY0
- Type
- protein
- Length
- 1,322 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1
- EC
- 2.7.10.2
- UniProt
- Q05397
- Pockets
- 11 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D, A, B | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 329 | 41% helix, 24% strand | Q05397 |
| C | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 335 | 40% helix, 24% strand | Q05397 |
Pockets
11 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 477 | 0.71 | 0.81 | 56 | empty |
| 2 | 441 | 0.71 | 0.81 | 41 | empty |
| 3 | 540 | 0.68 | 0.78 | 58 | empty |
| 4 | 542 | 0.68 | 0.78 | 59 | empty |
| 5 | 509 | 0.67 | 0.78 | 57 | empty |
Interfaces
3 interfaces between chains.
- A–C · 800 Ų buried · 8 hydrogen bonds · protein-protein
- D–B · 780 Ų buried · 5 hydrogen bonds · protein-protein
- D–A · 700 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05397
- Elsewhere: RCSB PDB 4NY0 · PDBe 4NY0 · UniProt Q05397
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