MolNFT v1 · #101626 · protein
Structure of a ptp-like phytase from bdellovibrio bacteriovorus
4NX8 · Protein-tyrosine phosphatase 2: “Structure of a ptp-like phytase from bdellovibrio bacteriovorus”. X-ray diffraction, 1 ligand (MG), 6 pockets (best druggability 0.74). MolNFT v1 #101626 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4NX8
- Type
- protein
- Length
- 520 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein-tyrosine phosphatase 2
- EC
- 3.1.3.48
- UniProt
- Q6MNP0
- Ligands
- MG
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein-tyrosine phosphatase 2 (EC 3.1.3.48) | protein | 261 | 43% helix, 19% strand | Q6MNP0 |
| B | Protein-tyrosine phosphatase 2 (EC 3.1.3.48) | protein | 259 | 40% helix, 19% strand | Q6MNP0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 413 | 0.74 | 0.84 | 51 | empty |
| 2 | 85 | 0.45 | 0.81 | 20 | empty |
| 3 | 143 | 0.45 | 0.76 | 26 | empty |
| 4 | 88 | 0.38 | 0.77 | 19 | empty |
| 5 | 71 | 0.31 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 678 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 4NX8 · Structure of a PTP-like phytase from Bdellovibrio bacteriovorus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6MNP0
- Elsewhere: RCSB PDB 4NX8 · PDBe 4NX8 · UniProt Q6MNP0
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