MolNFT v1 · #101566 · protein

Crystal structure of mesorhizobium loti arylamine N-acetyltransferase F42W mutant

4NV8: “Crystal structure of mesorhizobium loti arylamine N-acetyltransferase F42W mutant”. X-ray diffraction, 5 pockets (best druggability 0.78). MolNFT v1 #101566 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4NV8
Type: protein
Length: 538 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Arylamine N-acetyltransferase
EC: 2.3.1.5
UniProt: Q98D42
Pockets: 5 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Arylamine N-acetyltransferase (EC 2.3.1.5)	protein	270	32% helix, 28% strand	Q98D42
B	Arylamine N-acetyltransferase (EC 2.3.1.5)	protein	268	32% helix, 28% strand	Q98D42

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	106	0.78	0.98	29	empty
2	345	0.64	0.79	52	empty
3	365	0.64	0.79	55	empty
4	52	0.43	0.84	12	empty
5	56	0.26	0.73	15	empty

Interfaces

1 interface between chains.

A–B · 860 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

4NV8 · Crystal Structure of Mesorhizobium Loti Arylamine N-acetyltransferase F42W Mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q98D42
Elsewhere: RCSB PDB 4NV8 · PDBe 4NV8 · UniProt Q98D42

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.