Crystal structure of D60A mutant of arabidopsis ACD11 (accelerated- cell-death 11) complexed with C12 ceramide-1-phosphate (D18:1/12:0) at 2.55 ångström resolution

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 1% strand (DSSP).

Ligands and binding sites

• 1PZ · (2S,3R,4E)-2-(dodecanoylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 515 Ų buried · 9 hydrogen bonds · protein-protein

Compared structures

• 4NTG · Crystal structure of D60A mutant of Arabidopsis ACD11 (accelerated-cell-death 11)… · the same entry in another collection · chain A against A, TM-score 1.00
• O64587 · AlphaFold monomer V2.0 prediction for accelerated cell death 11 (O64587) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O64587
• Elsewhere: RCSB PDB 4NTG · PDBe 4NTG · UniProt O64587