MolNFT v1 · #10143 · protein
Solution structure of the DNA binding domain of HIV-1 integrase, NMR, minimized average structure
1IHV: “Solution structure of the DNA binding domain of HIV-1 integrase, NMR, minimized average structure”. Solution nmr, 2 pockets (best druggability 0.34). MolNFT v1 #10143 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1IHV
- Type
- protein
- Length
- 104 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HIV-1 integrase
- UniProt
- P04586
- Pockets
- 2 · best druggability 0.34
Structure
solution nmr · 1 distinct chain · 6% helix, 60% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | HIV-1 integrase | protein | 52 | 6% helix, 60% strand | P04586 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.34 | 0.76 | 18 | empty |
| 2 | 50 | 0.27 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 340 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1IHV · Solution structure of the DNA binding domain of HIV-1 integrase, NMR, minimized average… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04586
- Elsewhere: RCSB PDB 1IHV · PDBe 1IHV · UniProt P04586
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