MolNFT v1 · #100867 · protein

Crystal structure of the N-terminal domain of P15RS

4NAC · Regulation of nuclear pre-mRNA domain-containing protein 1A: “Crystal structure of the N-terminal domain of P15RS”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #100867 on GenesisL1: 3D structure, binding sites…

PDB: 4NAC
Type: protein
Length: 267 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulation of nuclear pre-mRNA domain-containing protein 1A
UniProt: Q96P16
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Regulation of nuclear pre-mRNA domain-containing protein 1A	protein	136	80% helix, 0% strand	Q96P16
B	Regulation of nuclear pre-mRNA domain-containing protein 1A	protein	131	80% helix, 0% strand	Q96P16

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	204	0.52	0.77	30	empty
2	70	0.31	0.74	11	empty

Interfaces

1 interface between chains.

A–B · 273 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

4NAC · Crystal Structure of the N-terminal Domain of p15RS · the same entry in another collection · chain A against A, TM-score 1.00
Q96P16 · AlphaFold monomer V2.0 prediction for regulation of nuclear pre-mRNA domain-containing… · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96P16
Elsewhere: RCSB PDB 4NAC · PDBe 4NAC · UniProt Q96P16

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