MolNFT v1 · #100795 · protein
Three-dimensional structure of the extracellular domain of matrix protein 2 of influenza a virus
4N8C · Heavy chain of monoclonal antibody: “Three-dimensional structure of the extracellular domain of matrix protein 2 of influenza a virus”. X-ray diffraction, 7 pockets (best druggability 0.54). MolNFT v1 #100795 on GenesisL1: 3D…
- PDB
- 4N8C
- Type
- protein
- Length
- 909 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heavy chain of monoclonal antibody; Light chain of monoclonal antibody; Extracellular…
- Pockets
- 7 · best druggability 0.54
Structure
x-ray diffraction · 6 distinct chains · 9% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Heavy chain of monoclonal antibody | protein | 220 | 10% helix, 51% strand | — |
| I | Heavy chain of monoclonal antibody | protein | 221 | 10% helix, 51% strand | — |
| L | Light chain of monoclonal antibody | protein | 219 | 6% helix, 51% strand | — |
| M | Light chain of monoclonal antibody | protein | 220 | 7% helix, 51% strand | — |
| X | Extracellular domain of influenza matrix protein 2 | protein | 15 | 20% helix, 0% strand | — |
| Y | Extracellular domain of influenza matrix protein 2 | protein | 14 | 21% helix, 0% strand | — |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 312 | 0.54 | 0.75 | 38 | empty |
| 2 | 262 | 0.53 | 0.76 | 34 | empty |
| 3 | 257 | 0.50 | 0.74 | 41 | empty |
| 4 | 92 | 0.33 | 0.73 | 24 | empty |
| 5 | 64 | 0.29 | 0.74 | 12 | empty |
Interfaces
8 interfaces between chains.
- I–M · 2106 Ų buried · 21 hydrogen bonds · protein-protein
- H–L · 1969 Ų buried · 20 hydrogen bonds · protein-protein
- I–Y · 422 Ų buried · 8 hydrogen bonds · protein-protein
- H–X · 419 Ų buried · 8 hydrogen bonds · protein-protein
- M–Y · 331 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 4N8C · Three-dimensional structure of the extracellular domain of Matrix protein 2 of influenza… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4N8C · PDBe 4N8C
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.