MolNFT v1 · #100639 · protein
Crystal structure of eukaryotic translation initiation factor EIF5B (517-1116) from chaetomium thermophilum, apo form
4N3N · Eukaryotic translation initiation factor 5B-like protein…: “Crystal structure of eukaryotic translation initiation factor EIF5B (517-1116) from chaetomium thermophilum…”. X-ray diffraction, 1 ligand (LAC), 5 pockets (best…
- PDB
- 4N3N
- Type
- protein
- Length
- 587 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 5B-like protein, EIF5B(517-C)
- UniProt
- G0S8G9
- Ligands
- LAC
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 5B-like protein, EIF5B(517-C) | protein | 587 | 34% helix, 29% strand | G0S8G9 |
Ligands and binding sites
- LAC · Lactic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 264 | 0.65 | 0.82 | 39 | empty |
| 2 | 181 | 0.47 | 0.75 | 25 | empty |
| 3 | 88 | 0.44 | 0.80 | 18 | empty |
| 4 | 108 | 0.39 | 0.75 | 25 | empty |
| 5 | 73 | 0.32 | 0.74 | 15 | empty |
Compared structures
- 4N3N · Crystal structure of eukaryotic translation initiation factor eIF5B (517-1116) from… · the same entry in another collection · chain A against A, TM-score 1.00
- G0S8G9 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 5B (G0S8G9) · a predicted model of the same protein · chain A against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S8G9
- Elsewhere: RCSB PDB 4N3N · PDBe 4N3N · UniProt G0S8G9
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