MolNFT v1 · #100525 · protein
The crystal structure of glyoxalase / bleomycin resistance protein from catenulispora acidiphila dsm 44928
4N04 · GLYOXALASE/BLEOMYCIN resistance PROTEIN/DIOXYGENASE: “The crystal structure of glyoxalase / bleomycin resistance protein from catenulispora acidiphila dsm 44928”. X-ray diffraction, 4 pockets (best druggability 0.51). MolNFT v1…
- PDB
- 4N04
- Type
- protein
- Length
- 221 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GLYOXALASE/BLEOMYCIN resistance PROTEIN/DIOXYGENASE
- UniProt
- C7Q893
- Pockets
- 4 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GLYOXALASE/BLEOMYCIN resistance PROTEIN/DIOXYGENASE | protein | 111 | 23% helix, 44% strand | C7Q893 |
| B | GLYOXALASE/BLEOMYCIN resistance PROTEIN/DIOXYGENASE | protein | 110 | 23% helix, 45% strand | C7Q893 |
Ligands and binding sites
- NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · 2 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 213 | 0.51 | 0.76 | 26 | NHE |
| 2 | 176 | 0.49 | 0.76 | 26 | NHE, GOL |
| 3 | 132 | 0.44 | 0.76 | 20 | empty |
| 4 | 105 | 0.41 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1401 Ų buried · 28 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (engineered).
Compared structures
- 4N04 · The crystal structure of glyoxalase / bleomycin resistance protein from Catenulispora… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C7Q893
- Elsewhere: RCSB PDB 4N04 · PDBe 4N04 · UniProt C7Q893
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.