MolNFT v1 · #10051 · protein

Solution structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis

1IEZ: “Solution structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis”. Solution nmr, 3 pockets (best druggability 0.59). MolNFT v1 #10051 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1IEZ
Type: protein
Length: 217 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3,4-dihydroxy-2-butanone 4-phosphate synthase
EC: 5.4.99.-
UniProt: P0A7J0
Pockets: 3 · best druggability 0.59

Structure

solution nmr · 1 distinct chain · 31% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3,4-dihydroxy-2-butanone 4-phosphate synthase (EC 5.4.99.-)	protein	217	31% helix, 11% strand	P0A7J0

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	114	0.59	0.85	21	empty
2	59	0.49	0.86	18	empty
3	96	0.36	0.75	20	empty

Compared structures

1IEZ · Solution Structure of 3,4-Dihydroxy-2-Buta 4-Phosphate Synthase of Riboflavin Biosynthesis · the same entry in another collection · chain A against A, TM-score 1.00
P0A7J0 · AlphaFold monomer V2.0 prediction for 3,4-dihydroxy-2-butanone 4-phosphate synthase… · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A7J0
Elsewhere: RCSB PDB 1IEZ · PDBe 1IEZ · UniProt P0A7J0

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