MolNFT v1 · #100443 · protein

Crystal structure of trypanosoma cruzi formiminoglutamase with MN2+2

4MXR: “Crystal structure of trypanosoma cruzi formiminoglutamase with MN2+2”. X-ray diffraction, 1 ligand (MN), 3 pockets (best druggability 0.59). MolNFT v1 #100443 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4MXR
Type: protein
Length: 594 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Formiminoglutamase
EC: 3.5.3.8
UniProt: Q4DSA0
Ligands: MN
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Formiminoglutamase (EC 3.5.3.8)	protein	297	43% helix, 20% strand	Q4DSA0

Ligands and binding sites

MN · Manganese (II) ion · metal · 4 copies · chains A, B
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	510	0.59	0.73	44	empty
2	73	0.48	0.84	21	empty
3	56	0.42	0.83	15	empty

Interfaces

1 interface between chains.

A–B · 74 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4MXR · Crystal structure of Trypanosoma cruzi formiminoglutamase with Mn2+2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4DSA0
Elsewhere: RCSB PDB 4MXR · PDBe 4MXR · UniProt Q4DSA0

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.