MolNFT v1 · #100316 · protein

Structure of the ERS1 dimerization and histidine phosphotransfer domain from arabidopsis thaliana

4MTX · Ethylene response sensor 1: “Structure of the ERS1 dimerization and histidine phosphotransfer domain from arabidopsis thaliana”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #100316 on GenesisL1: 3D structure…

PDB: 4MTX
Type: protein
Length: 384 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ethylene response sensor 1
EC: 2.7.11.-, 2.7.13.3
UniProt: Q38846
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 3 distinct chains · 90% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ethylene response sensor 1 (EC 2.7.11.-, 2.7.13.3)	protein	96	90% helix, 0% strand	Q38846
C	Ethylene response sensor 1 (EC 2.7.11.-, 2.7.13.3)	protein	97	89% helix, 0% strand	Q38846
D	Ethylene response sensor 1 (EC 2.7.11.-, 2.7.13.3)	protein	95	91% helix, 0% strand	Q38846

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.35	0.77	15	empty

Interfaces

4 interfaces between chains.

C–D · 2174 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 2171 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 453 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 359 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 28 modified (engineered).

Compared structures

4MTX · Structure of the ERS1 dimerization and histidine phosphotransfer domain from Arabidopsis… · the same entry in another collection · chain D against D, TM-score 1.00
Q38846 · AlphaFold monomer V2.0 prediction for ethylene response sensor 1 (Q38846) · a predicted model of the same protein · chain C against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q38846
Elsewhere: RCSB PDB 4MTX · PDBe 4MTX · UniProt Q38846

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