MolNFT v1 · #100283 · protein

Crystal structure of an essential yeast splicing factor

4MSX · Pre-mRNA-splicing factor SAD1: “Crystal structure of an essential yeast splicing factor”. X-ray diffraction, 1 ligand (ZN), 4 pockets (best druggability 0.70). MolNFT v1 #100283 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 4MSX
Type: protein
Length: 395 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-splicing factor SAD1
UniProt: P43589
Ligands: ZN
Pockets: 4 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA-splicing factor SAD1	protein	395	31% helix, 27% strand	P43589

Ligands and binding sites

ZN · Zinc ion · metal · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	273	0.70	0.85	28	empty
2	110	0.57	0.85	22	empty
3	114	0.39	0.75	22	empty
4	56	0.29	0.75	17	empty

Compared structures

4MSX · Crystal structure of an essential yeast splicing factor · the same entry in another collection · chain A against A, TM-score 1.00
P43589 · AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor SAD1 (P43589) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43589
Elsewhere: RCSB PDB 4MSX · PDBe 4MSX · UniProt P43589

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